HRID1875742

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7738

(4-Methoxyphenyl)methanol

C8H10O2

反应SMILES：COC(=O)CCc1ccc(Cn2c(-c3cccnc3Cl)nc3cc(F)c(F)cc32)cc1

HCID86652288

未命名化合物

PRODUCTS

产物

反应SMILES：COC(=O)CCc1ccc(Cn2c(-c3cccnc3OCc3ccc(OC)cc3)nc3cc(F)c(F)cc32)cc1

HCID67050035

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 4, intermediate, from 3-{4-[2-(2-chloro-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid methyl ester and (4-methoxy-phenyl)-methanol (CAS Reg. No. 105-13-5). Colorless sticky solid (81%). MS (Turbo Spray): m/z=544.1 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-da27f4c3222a4fc580c9f9df92b7197d
来源数据集: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08309581B2
来源说明: uspto-grants-2012_11

反应SMILES

[CH3:1][O:2][C:3](=[O:31])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[C:17]3[CH:18]=[C:19]([F:23])[C:20]([F:22])=[CH:21][C:16]=3[N:15]=[C:14]2[C:24]2[C:25](Cl)=[N:26][CH:27]=[CH:28][CH:29]=2)=[CH:8][CH:7]=1.[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([CH2:40][OH:41])=[CH:36][CH:35]=1>>[CH3:1][O:2][C:3](=[O:31])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[C:17]3[CH:18]=[C:19]([F:23])[C:20]([F:22])=[CH:21][C:16]=3[N:15]=[C:14]2[C:24]2[C:25]([O:41][CH2:40][C:37]3[CH:38]=[CH:39][C:34]([O:33][CH3:32])=[CH:35][CH:36]=3)=[N:26][CH:27]=[CH:28][CH:29]=2)=[CH:8][CH:7]=1