4-Methoxybenzyl alcohol → 3-(4-{5,6-Difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-benzoimidazol-1-ylmethyl}-phenyl)-propionic acid methyl ester

HRID 1875742Notes

Reaction equation

HRID 1875742 reaction equation
[CH3:1][O:2][C:3](=[O:31])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[C:17]3[CH:18]=[C:19]([F:23])[C:20]([F:22])=[CH:21][C:16]=3[N:15]=[C:14]2[C:24]2[C:25](Cl)=[N:26][CH:27]=[CH:28][CH:29]=2)=[CH:8][CH:7]=1.[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([CH2:40][OH:41])=[CH:36][CH:35]=1>>[CH3:1][O:2][C:3](=[O:31])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[C:17]3[CH:18]=[C:19]([F:23])[C:20]([F:22])=[CH:21][C:16]=3[N:15]=[C:14]2[C:24]2[C:25]([O:41][CH2:40][C:37]3[CH:38]=[CH:39][C:34]([O:33][CH3:32])=[CH:35][CH:36]=3)=[N:26][CH:27]=[CH:28][CH:29]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 77384-Methoxybenzyl alcoholHCID 866522883-{4-[2-(2-Chloro-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid methyl ester

Product 1

HCID 670500353-(4-{5,6-Difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-benzoimidazol-1-ylmethyl}-phenyl)-propionic acid methyl ester

Procedure

The title compound was prepared in analogy to Example 4, intermediate, from 3-{4-[2-(2-chloro-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid methyl ester and (4-methoxy-phenyl)-methanol (CAS Reg. No. 105-13-5). Colorless sticky solid (81%). MS (Turbo Spray): m/z=544.1 (M+H).

Sources & evidence

ORD record
ord-da27f4c3222a4fc580c9f9df92b7197d
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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