Cyclohexane, (bromomethyl)- → 1-Cyclohexylmethyl-5,6-difluoro-2-(2-methoxy-phenyl)-1H-benzoimidazole

HRID 1875764Notes

Reaction equation

HRID 1875764 reaction equation
C1([CH2:4][O:5][C:6]2[C:11]([C:12]3[N:16]([CH2:17][C:18]4[CH:23]=[CH:22][C:21](CCC(O)=O)=[CH:20][CH:19]=4)[C:15]4[CH:29]=[C:30]([F:34])[C:31]([F:33])=[CH:32][C:14]=4[N:13]=3)=[CH:10]C=CN=2)CC1.F[C:36]1[C:52](F)=CC2NC(C3C=CC=CC=3OC)=NC=2[CH:37]=1.BrCC1CCCCC1>>[CH:18]1([CH2:17][N:16]2[C:15]3[CH:29]=[C:30]([F:34])[C:31]([F:33])=[CH:32][C:14]=3[N:13]=[C:12]2[C:11]2[CH:10]=[CH:52][CH:36]=[CH:37][C:6]=2[O:5][CH3:4])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1

Participants

4

Reactant 3

HCID 137636Cyclohexane, (bromomethyl)-HCID 510396793-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acidHCID 609804125,6-Difluoro-2-(2-methoxyphenyl)-1H-benzo[D]imidazole

Product 1

HCID 670498311-Cyclohexylmethyl-5,6-difluoro-2-(2-methoxy-phenyl)-1H-benzoimidazole

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 5,6-difluoro-2-(2-methoxy-phenyl)-1H-benzoimidazole and bromomethyl-cyclohexane (2550-36-9). Brown sticky solid (42%). MS (Turbo Spray): m/z=357.4 (M+H).

Sources & evidence

ORD record
ord-45387c0dd46e40d4b73881865d80e6cc
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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