HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexane, (bromomethyl)- → 1-Cyclohexylmethyl-5,6-difluoro-2-(2-methoxy-phenyl)-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexane, (bromomethyl)- | HCID 137636 | — |
| Reactant | 3-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid | HCID 51039679 | — |
| Reactant | 5,6-Difluoro-2-(2-methoxyphenyl)-1H-benzo[D]imidazole | HCID 60980412 | — |
| Product | 1-Cyclohexylmethyl-5,6-difluoro-2-(2-methoxy-phenyl)-1H-benzoimidazole | HCID 67049831 | — |
Reaction Steps
The title compound was prepared in analogy to Example 19, intermediate b, from 5,6-difluoro-2-(2-methoxy-phenyl)-1H-benzoimidazole and bromomethyl-cyclohexane (2550-36-9). Brown sticky solid (42%). MS (Turbo Spray): m/z=357.4 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-45387c0dd46e40d4b73881865d80e6cc |
| Source note | uspto-grants-2012_11 |