Cyclohexane, (bromomethyl)- → 2-(4-Chloro-2-methoxy-phenyl)-1-cyclohexylmethyl-1H-benzoimidazole

HRID 1875767Notes

Reaction equation

HRID 1875767 reaction equation
C1([CH2:4][O:5][C:6]2[C:11]([C:12]3[N:16]([CH2:17][C:18]4[CH:23]=[CH:22][C:21](CCC(O)=O)=[CH:20][CH:19]=4)[C:15]4[CH:29]=[C:30](F)[C:31](F)=[CH:32][C:14]=4[N:13]=3)=[CH:10][CH:9]=CN=2)CC1.[Cl:35][C:36]1C=CC(C2NC3C=CC=CC=3N=2)=C(OC)[CH:37]=1.BrCC1CCCCC1>>[Cl:35][C:36]1[CH:9]=[CH:10][C:11]([C:12]2[N:16]([CH2:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:15]3[CH:29]=[CH:30][CH:31]=[CH:32][C:14]=3[N:13]=2)=[C:6]([O:5][CH3:4])[CH:37]=1

Participants

4

Reactant 3

HCID 137636Cyclohexane, (bromomethyl)-HCID 510396793-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acidHCID 617258442-(4-Chloro-2-methoxy-phenyl)-1H-benzoimidazole

Product 1

HCID 670500642-(4-Chloro-2-methoxy-phenyl)-1-cyclohexylmethyl-1H-benzoimidazole

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-Chloro-2-methoxy-phenyl)-1H-benzoimidazole and bromomethyl-cyclohexane (CAS Reg. No 2550-36-9). Brown solid (48%). MS (Turbo Spray): m/z=355.3 (M+H).

Sources & evidence

ORD record
ord-383126e2e09142f99ea62c2530311d9f
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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