HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexane, (bromomethyl)- → 2-(4-Chloro-2-methoxy-phenyl)-1-cyclohexylmethyl-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexane, (bromomethyl)- | HCID 137636 | — |
| Reactant | 3-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid | HCID 51039679 | — |
| Reactant | 2-(4-Chloro-2-methoxy-phenyl)-1H-benzoimidazole | HCID 61725844 | — |
| Product | 2-(4-Chloro-2-methoxy-phenyl)-1-cyclohexylmethyl-1H-benzoimidazole | HCID 67050064 | — |
Reaction Steps
The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-Chloro-2-methoxy-phenyl)-1H-benzoimidazole and bromomethyl-cyclohexane (CAS Reg. No 2550-36-9). Brown solid (48%). MS (Turbo Spray): m/z=355.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-383126e2e09142f99ea62c2530311d9f |
| Source note | uspto-grants-2012_11 |