HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexane, (bromomethyl)- → 4-[2-(1-Cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexane, (bromomethyl)- | HCID 137636 | — |
| Reactant | 3-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid | HCID 51039679 | — |
| Reactant | 4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile | HCID 67049932 | — |
| Product | 4-[2-(1-Cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile | HCID 67049606 | — |
Reaction Steps
The compound was prepared in analogy to Example 19, intermediate b, from 4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile and bromomethyl-cyclohexane (CAS Reg. No. 2550-36-9). Yellow powder (69%). MS (Turbo Spray): m/z=476.4 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-3fd6ffec070d4d5ea9d1745133e794e5 |
| Source note | uspto-grants-2012_11 |