(Iodomethyl)cyclopentane → HCID 67049990, compound

HRID 1875778Notes

Reaction equation

HRID 1875778 reaction equation
C1(COC2C(C3N(CC4C=CC(CCC(O)=O)=CC=4)C4C=C(F)C(F)=CC=4N=3)=CC=CN=2)CC1.[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[N:46]([CH2:47][CH:48]3[CH2:53][CH2:52][CH2:51]C[CH2:49]3)[C:45]3[CH:54]=[C:55]([F:59])[C:56]([F:58])=[CH:57][C:44]=3[N:43]=2)=[C:38]([O:60][CH2:61]C2C=CC=CC=2Cl)[CH:37]=1.ICC1CCCC1>>[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[N:46]([CH2:47][CH:48]3[CH2:49][CH2:51][CH2:52][CH2:53]3)[C:45]3[CH:54]=[C:55]([F:59])[C:56]([F:58])=[CH:57][C:44]=3[N:43]=2)=[C:38]([O:60][CH3:61])[CH:37]=1

Participants

4

Reactant 3

HCID 2762531(Iodomethyl)cyclopentaneHCID 510396793-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acidHCID 582092722-[4-Chloro-2-(2-chloro-benzyloxy)-phenyl]-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole2×

Product 1

HCID 67049990HCID 67049990, compound

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-chloro-2-methoxy-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 19, intermediate c) and iodomethyl-cyclopentane (CAS Reg. No. 27935-87-1). Brown sticky solid (50%). MS (Turbo Spray): m/z=377.1 (M+H).

Sources & evidence

ORD record
ord-246e09fd88a14036ae05207b322e6426
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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