Bromomethylcyclopropane → HCID 58209256, compound

HRID 1875790Notes

Reaction equation

HRID 1875790 reaction equation
[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[OH:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:28][CH:29]1[CH2:31][CH2:30]1>>[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[O:26][CH2:28][CH:29]1[CH2:31][CH2:30]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 136378483HCID 136378483, compound

Product 1

HCID 58209256HCID 58209256, compound

Procedure

The title compound was prepared in analogy to Example 19, from 2-(1-benzyl-5,6-difluoro-1H-benzoimidazol-2-yl)-5-chloro-phenol (Example 48, intermediate a) and bromomethyl-cyclopropane (CAS Reg. No. 7051-34-5). Colorless powder (70%). MS (Turbo Spray): m/z=425.3 (M+H).

Sources & evidence

ORD record
ord-b7fab2a6b04f456a8310a8217c623599
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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