(Bromomethyl)cyclopentane → 3-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzonitrile

HRID 1875810Notes

Reaction equation

HRID 1875810 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=3)[C:17]#[N:18])[C:11]3[CH:22]=[C:23]([F:27])[C:24]([F:26])=[CH:25][C:10]=3[N:9]=2)=[C:4]([OH:28])[CH:3]=1.Br[CH2:30][CH:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=3)[C:17]#[N:18])[C:11]3[CH:22]=[C:23]([F:27])[C:24]([F:26])=[CH:25][C:10]=3[N:9]=2)=[C:4]([O:28][CH2:30][CH:31]2[CH2:35][CH2:34][CH2:33][CH2:32]2)[CH:3]=1

Participants

3

Reactant 2

HCID 12723264(Bromomethyl)cyclopentaneHCID 1363784993-[2-(4-Chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzonitrile

Product 1

HCID 670504513-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzonitrile

Procedure

The title compound was prepared in analogy to Example 19, from 3-[2-(4-chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzonitrile and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Brown solid (33%). MS (Turbo Spray): m/z=378.2 (M+H).

Sources & evidence

ORD record
ord-9206c35ac4e44755b6358ac5cdfc4856
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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