Methyl bromoacetate → HCID 67050107, compound

HRID 1875829Notes

Reaction equation

[CH:1]1([CH2:7][N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:32][O:33][C:34](=[O:37])[CH2:35]Br>>[CH3:32][O:33][C:34](=[O:37])[CH2:35][O:31][C:28]1[CH:27]=[CH:26][C:25]([CH2:24][CH2:23][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[C:9]2[N:8]([CH2:7][CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=2)=[CH:30][CH:29]=1

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 67049786HCID 67049786, compound

Product 1

HCID 67050107HCID 67050107, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 4-{2-[2-(1-cyclohexylmethyl-1H-benzoimidazol-2-yl)-phenyl]-ethyl}-phenol and bromo-acetic acid methyl ester (CAS Reg. No. 96-32-2). Off-white semi-solid (77%). MS (Turbo Spray): m/z=497.4 (M+H).

Sources & evidence

ORD record: ord-b9808357fc8a4787958b10f3812ab4b2
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309581B2

Reaction notes

Loading…