1-Ethynyl-4-methoxybenzene → 1-Cyclohexylmethyl-2-[2-(4-methoxy-phenylethynyl)-phenyl]-1H-benzoimidazole

HRID 1875830Notes

Reaction equation

HRID 1875830 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]([CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:11]2[CH:20]=[CH:21][CH:22]=[CH:23][C:10]=2[N:9]=1.[C:24]([C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=1)#[CH:25]>>[CH:14]1([CH2:13][N:12]2[C:11]3[CH:20]=[CH:21][CH:22]=[CH:23][C:10]=3[N:9]=[C:8]2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[C:25]#[C:24][C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 2510201-Ethynyl-4-methoxybenzeneHCID 67050067HCID 67050067, compound

Product 1

HCID 670501481-Cyclohexylmethyl-2-[2-(4-methoxy-phenylethynyl)-phenyl]-1H-benzoimidazole

Procedure

The title compound was prepared in analogy to Example 72, intermediate a, from 2-(2-bromo-phenyl)-1-cyclohexylmethyl-1H-benzoimidazole and 1-ethynyl-4-methoxy-benzene (CAS Reg. No. 768-60-5). Yellow sticky solid (24%). MS (Turbo Spray): m/z=421.4 (M+H).

Sources & evidence

ORD record
ord-947fd255b8804d8084ac59a53f04b3f0
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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