2-(2-Bromophenyl)-1H-benzimidazole → 2-(2-bromo-phenyl)-1-cyclohexylmethyl-1H-benzoimidazole

HRID 1875831Notes

Reaction equation

HRID 1875831 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][C:17](CCC(O)=O)=[CH:16][CH:15]=3)[C:11]3[CH:25]=[C:26](F)[C:27](F)=[CH:28][C:10]=3[N:9]=2)=[C:4](OCC2CCCC2)[CH:3]=1.[Br:38]C1C=CC=CC=1C1NC2C=CC=CC=2N=1.BrCC1CCCCC1>>[Br:38][C:4]1[CH:3]=[CH:2][CH:7]=[CH:6][C:5]=1[C:8]1[N:12]([CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:11]2[CH:25]=[CH:26][CH:27]=[CH:28][C:10]=2[N:9]=1

Participants

4

Reactant 3

HCID 975112-(2-Bromophenyl)-1H-benzimidazoleHCID 137636Cyclohexane, (bromomethyl)-HCID 582092583-{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid

Product 1

HCID 670500672-(2-bromo-phenyl)-1-cyclohexylmethyl-1H-benzoimidazole

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(2-bromo-phenyl)-1H-benzoimidazole and bromomethyl-cyclohexane (CAS Reg. No. 2550-36-9). Light brown solid (62%). MS (Turbo Spray): m/z=369.4 (M+H).

Sources & evidence

ORD record
ord-c910f832dbb94d4b921d950ee6a8c045
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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