4-Ethynylbenzonitrile → HCID 67050136, compound

HRID 1875834Notes

Reaction equation

HRID 1875834 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]([CH2:13][CH:14]2[CH2:19][CH2:18][C:17]([F:21])([F:20])[CH2:16][CH2:15]2)[C:11]2[CH:22]=[CH:23][CH:24]=[CH:25][C:10]=2[N:9]=1.[C:26]([C:28]1[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][CH:29]=1)#[CH:27]>>[F:21][C:17]1([F:20])[CH2:18][CH2:19][CH:14]([CH2:13][N:12]2[C:11]3[CH:22]=[CH:23][CH:24]=[CH:25][C:10]=3[N:9]=[C:8]2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[C:27]#[C:26][C:28]2[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][CH:29]=2)[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 45472454-EthynylbenzonitrileHCID 67050023HCID 67050023, compound

Product 1

HCID 67050136HCID 67050136, compound

Procedure

The title compound was prepared in analogy to Example 72, intermediate a, from 2-(2-bromo-phenyl)-1-(4,4-difluoro-cyclohexylmethyl)-1H-benzoimidazole and 4-ethynyl-benzonitrile (CAS Reg. No. 3032-92-6). Brown solid (38%). MS (Turbo Spray): m/z=452.2 (M+H).

Sources & evidence

ORD record
ord-1ec893e470474af78c5beb9f21300bc7
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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