4-Ethynylbenzonitrile → HCID 67049928, compound

HRID 1875835Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]([CH2:13][CH:14]2[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]2)[C:11]2[CH:21]=[CH:22][CH:23]=[CH:24][C:10]=2[N:9]=1.[C:25]([C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][CH:28]=1)#[CH:26]>>[CH3:20][CH:17]1[CH2:18][CH2:19][CH:14]([CH2:13][N:12]2[C:11]3[CH:21]=[CH:22][CH:23]=[CH:24][C:10]=3[N:9]=[C:8]2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[C:26]#[C:25][C:27]2[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][CH:28]=2)[CH2:15][CH2:16]1

Participants

Reactant 2

HCID 45472454-Ethynylbenzonitrile

HCID 67049843HCID 67049843, compound

Product 1

HCID 67049928HCID 67049928, compound

Procedure

The title compound was prepared in analogy to Example 72, intermediate a, from 2-(2-bromo-phenyl)-1-(4-methyl-cyclohexylmethyl)-1H-benzoimidazole and 4-ethynyl-benzonitrile (CAS Reg. No. 3032-92-6). Light yellow liquid (25%). MS (Turbo Spray): m/z=430.4 (M+H).

Sources & evidence

ORD record: ord-3201de817b174db38e3e26d6f9826687
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309581B2

Reaction notes

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