4-Ethynylbenzonitrile → HCID 67049672, compound

HRID 1875836Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]([CH2:13]C2CCC(C)CC2)[C:11]2[CH:21]=[CH:22][CH:23]=[CH:24][C:10]=2[N:9]=1.[C:25]([C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][CH:28]=1)#[CH:26]>>[CH:3]1([CH2:8][CH2:13][N:12]2[C:11]3[CH:21]=[CH:22][CH:23]=[CH:24][C:10]=3[N:9]=[C:8]2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[C:26]#[C:25][C:27]2[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][CH:28]=2)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:2]1

Participants

Reactant 2

HCID 45472454-Ethynylbenzonitrile

HCID 67049843HCID 67049843, compound

Product 1

HCID 67049672HCID 67049672, compound

Procedure

The title compound was prepared in analogy to Example 72, intermediate a, from 2-(2-bromo-phenyl)-1-(4-methyl-cyclohexylmethyl)-1H-benzoimidazole and 4-ethynyl-benzonitrile (CAS Reg. No. 3032-92-6). White solid (43%). MS (Turbo Spray): m/z=430.2 (M+H).

Sources & evidence

ORD record: ord-e70886aaab994e69b0c7e62f5e494309
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309581B2

Reaction notes

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