Imidazole → HCID 12623182, compound

HRID 1875852Notes

Reaction equation

HRID 1875852 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Cl[C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9]>O1CCCC1>[N:1]1([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 20884Ethoxalyl chloride

Product 1

HCID 12623182HCID 12623182, compoundYield 95.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of imidazole (12.2 g, 175 mmol) in tetrahydrofuran (250 ml) was added ethyl chlorooxoacetate (10 mL, 90 mmol) in tetrahydrofuran (250 ml) at 0° C., and the mixture was stirred for 1 hour and then filtered off and washed with cold tetrahydarofuran (100 mL). The solvent was evaporated off under the reduced pressure to obtain 14.4 g of the title compound.

Workup

  1. filtrationfiltered off
  2. washwashed with cold tetrahydarofuran (100 mL)
  3. customThe solvent was evaporated off under the reduced pressure

Sources & evidence

ORD record
ord-3b753ec5a70f44eda0286fe29e56184f
Source dataset
uspto-grants-2012_11
Patent number
US08309584B2

Reaction notes

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