HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-Hydroxypyridine → (1,3)Oxazolo(4,5-b)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-Hydroxypyridine | HCID 28114 | — |
| Reactant | 1-(1H-imidazole-1-carboximidoyl)-1H-imidazole | HCID 11355654 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (1,3)Oxazolo(4,5-b)pyridin-2-amine | HCID 12730674 | — |
Reaction Steps
An oven dried round bottom flask was charged with di(1H-imidazol-1-yl)methanimine (500 mg, 3.10 mmol), 2-aminopyridin-3-ol (171 mg, 1.551 mmol) and anhydrous THF (20 ml) at room temperature. The resulting suspension was refluxed under N2 for 1 hr. LC/MS indicated complete consumption of starting material. The solvent was removed in vacuo and the residue was used in the next step without further purification. MS (LC/MS) R.T.=0.235; [M+H]+=136.09.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309577B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-41fb90b30a3745efb1d4e96df70035d9 |
| Source note | uspto-grants-2012_11 |