反应详情

An oven dried round bottom flask was charged with di(1H-imidazol-1-yl)methanimine (500 mg, 3.10 mmol), 2-aminopyridin-3-ol (171 mg, 1.551 mmol) and anhydrous THF (20 ml) at room temperature. The resulting suspension was refluxed under N2 for 1 hr. LC/MS indicated complete consumption of starting material. The solvent was removed in vacuo and the residue was used in the next step without further purification. MS (LC/MS) R.T.=0.235; [M+H]+=136.09.

1. customAn oven dried round bottom flask
2. temperatureThe resulting suspension was refluxed under N2 for 1 hr
3. customconsumption of starting material
4. customThe solvent was removed in vacuo
5. customthe residue was used in the next step without further purification
6. customMS (LC/MS) R.T.=0.235