P-Anisidine → HCID 3866276, compound

HRID 1876060Notes

Reaction equation

HRID 1876060 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][O:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[Cl:1][C:2]1[N:11]=[C:10]([NH:19][C:18]2[CH:20]=[CH:21][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 3866276HCID 3866276, compound

Procedure

The title compound was prepared from 2,4-dichloroquinazoline (50 mg, 0.251 mmol) and 4-methoxyaniline (45 mg, 0.326 mmol) by a procedure similar to Example 1b and was isolated as off white powder (55 mg, 77%). 1H NMR (CDCl3): 10.25 (s, 1H), 8.58 (d, J=8.4 Hz, 1H), 7.88 (t, J=7.2 Hz, 1H), 7.71-7.63 (m, 4H), 7.03-6.99 (m, 2H), 3.79 (s, 3H).

Sources & evidence

ORD record
ord-21088177793c4da4a5f206d28336a3d6
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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