Ammonia → (2-Amino-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine

HRID 1876065Notes

Reaction equation

HRID 1876065 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH3:22]>CO>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([N:12]([CH3:13])[C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([NH2:22])[N:11]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 117381122-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine

Product 1

HCID 11323466(2-Amino-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Title compound was prepared from (2-chloro-quinazolin-4-yl)-(4-methoxy-phenyl)-methyl-amine (10 mg, 0.033 mmol) and 7 M ammonia in methanol (1 mL) by a procedure similar to Example 10 (5 mg, 50%). 1H NMR (CDCl3): 7.44 (m, 2H), 7.16 (m, 2H), 6.96-6.95 (m, 2H), 6.88 (dd, J=8.4 and 1.5 Hz, 1H), 6.72 (ddd, J=8.7, 6.6 and 1.8 Hz, 1H), 3.86 (s, 3H), 3.72 (s, 3H).

Sources & evidence

ORD record
ord-1f895a3bfe3d453d9569174f8925a038
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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