Ammonia → (2-Amino-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine	HCID 11738112	—
Solvent	Methanol	HCID 887	—
Product	(2-Amino-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine	HCID 11323466	—

Reaction Steps

Title compound was prepared from (2-chloro-quinazolin-4-yl)-(4-methoxy-phenyl)-methyl-amine (10 mg, 0.033 mmol) and 7 M ammonia in methanol (1 mL) by a procedure similar to Example 10 (5 mg, 50%). 1H NMR (CDCl3): 7.44 (m, 2H), 7.16 (m, 2H), 6.96-6.95 (m, 2H), 6.88 (dd, J=8.4 and 1.5 Hz, 1H), 6.72 (ddd, J=8.7, 6.6 and 1.8 Hz, 1H), 3.86 (s, 3H), 3.72 (s, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08309562B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-1f895a3bfe3d453d9569174f8925a038
Source note	uspto-grants-2012_11