N-Methyl-4-anisidine → HCID 178492251, compound

HRID 1876068Notes

Reaction equation

HRID 1876068 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4](Cl)[N:3]=1.[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([NH:18][CH3:19])=[CH:16][CH:15]=1>>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([N:18]([CH3:19])[C:4]2[N:3]=[C:2]([NH2:1])[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][NH:8]3)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 22250N-Methyl-4-anisidineHCID 1785084356-chloro-1H-purin-2-amine

Product 1

HCID 178492251HCID 178492251, compound

Procedure

The title compound was prepared from 2-amino-6-chloro-9H-purine (100 mg, 0.546 mmol) and 4-methoxy-N-methyl-aniline (127 mg, 0.656 mmol) by a procedure similar to Example 1b and was isolated as white powder (5 mg, 5%). 1H NMR (CDCl3): 7.54 (s, 1H), 7.25 (d, J=8.7 Hz, 2H), 6.98 (d, J=8.7 Hz, 2H), 3.86 (s, 3H), 3.66 (s, 3H).

Sources & evidence

ORD record
ord-54921ed317624af3a0bd68a459052d80
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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