2,4-Dimethoxyaniline → ST51026431

HRID 1876079Notes

Reaction equation

HRID 1876079 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][O:14][C:15]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:16]=1[NH2:17]>>[Cl:1][C:2]1[N:11]=[C:10]([NH:17][C:16]2[CH:18]=[CH:19][C:20]([O:22][CH3:23])=[CH:21][C:15]=2[O:14][CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 176522,4-DimethoxyanilineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 2390050ST51026431

Procedure

The title compound was prepared from 2,4-dichloroquinazoline and 2,4-dimethoxyaniline by a procedure similar to Example 28 (92% yield). 1H NMR (CDCl3): 8.59 (d, J=8.7 Hz, 1H), 8.22 (s, broad, 1H), 7.75-7.81 (m, 3H), 7.52 (ddd, J=8.4, 6.6 and 2.1 Hz, 1H), 6.52-6.59 (m, 2H), 3.95 (s, 3H), 3.82 (s, 3H).

Sources & evidence

ORD record
ord-0a26f15127be4003b8d1dd52a5e00fcf
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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