3-Fluoro-4-methoxyaniline → N-(3-Fluoro-4-methoxyphenyl)-2-methylquinazolin-4-amine

HRID 1876110Notes

Reaction equation

HRID 1876110 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.[F:13][C:14]1[CH:15]=[C:16]([NH2:22])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]>>[F:13][C:14]1[CH:15]=[C:16]([NH:22][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH3:12])[N:3]=2)[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]

Participants

3

Reactant 2

HCID 5811103-Fluoro-4-methoxyanilineHCID 27854214-Chloro-2-methylquinazoline

Product 1

HCID 42625836N-(3-Fluoro-4-methoxyphenyl)-2-methylquinazolin-4-amine

Procedure

The title compound was prepared from 4-chloro-2-methyl-quinazoline (150 mg, 0.84 mmol), 3-fluoro-4-methoxy-phenylamine (1 18.5 mg, 0.84 mmol) by a procedure similar to Example 78. 1H NMR (CDCl3): 7.89-7.75 (m, 4H), 7.53-7.48 (m, 1H)), 7.38-7.34 (m, 2H), 7.0 (t, J=8.7 Hz, 1H), 3.92 (s, 3H), 2.71 (s, 3H).

Sources & evidence

ORD record
ord-e6802e3e97d64a41bb215d508c7d90c1
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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