Methyl iodide → (4-Isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methyl-amine

HRID 1876117Notes

Reaction equation

HRID 1876117 reaction equation
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]([CH3:22])[N:13]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[CH3:23]I>>[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([N:11]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]([CH3:22])[N:13]=2)[CH3:23])=[CH:9][CH:10]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 579388052-Methyl-N-{4-[(propan-2-yl)oxy]phenyl}quinazolin-4-amine

Product 1

HCID 11370251(4-Isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methyl-amine

Procedure

The title compound was prepared from (4-isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (164.3 mg, 0.56 mmol) and methyl iodide (0.25 ml, 3.92 mmol) by a procedure similar to Example 36. 1H NMR (CDCl3): 7.73 (d, J=7.8 Hz, 1H), 7.54-7.49 (m, 1H), 7.10-6.86 (m, 6H), 4.57-4.52 (m, 1H), 3.58 (s, 3H), 2.72 (s, 3H), 1.36 (d, J=6 Hz, 6H).

Sources & evidence

ORD record
ord-1ea97fd663854036af9207884e88e1d0
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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