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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1876117Generated: November 1, 2026

Methyl iodide → (4-Isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methyl-amine

https://huagongshe.com/reaction/1876117

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
Reactant2-Methyl-N-{4-[(propan-2-yl)oxy]phenyl}quinazolin-4-amineHCID 57938805—
Product(4-Isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methyl-amineHCID 11370251—

Reaction Steps

The title compound was prepared from (4-isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (164.3 mg, 0.56 mmol) and methyl iodide (0.25 ml, 3.92 mmol) by a procedure similar to Example 36. 1H NMR (CDCl3): 7.73 (d, J=7.8 Hz, 1H), 7.54-7.49 (m, 1H), 7.10-6.86 (m, 6H), 4.57-4.52 (m, 1H), 3.58 (s, 3H), 2.72 (s, 3H), 1.36 (d, J=6 Hz, 6H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08309562B2
Source datasetuspto-grants-2012_11
ORD IDord-1ea97fd663854036af9207884e88e1d0
Source noteuspto-grants-2012_11