HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (4-Isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2-Methyl-N-{4-[(propan-2-yl)oxy]phenyl}quinazolin-4-amine | HCID 57938805 | — |
| Product | (4-Isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methyl-amine | HCID 11370251 | — |
Reaction Steps
The title compound was prepared from (4-isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (164.3 mg, 0.56 mmol) and methyl iodide (0.25 ml, 3.92 mmol) by a procedure similar to Example 36. 1H NMR (CDCl3): 7.73 (d, J=7.8 Hz, 1H), 7.54-7.49 (m, 1H), 7.10-6.86 (m, 6H), 4.57-4.52 (m, 1H), 3.58 (s, 3H), 2.72 (s, 3H), 1.36 (d, J=6 Hz, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309562B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-1ea97fd663854036af9207884e88e1d0 |
| Source note | uspto-grants-2012_11 |