Methyl iodide → 4-Quinazolinamine, N,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-

HRID 1876119Notes

Reaction equation

HRID 1876119 reaction equation
[CH3:1][C:2]1[N:11]=[C:10]([NH:12][C:13]2[C:18]([O:19][CH3:20])=[CH:17][C:16]([O:21][CH3:22])=[CH:15][C:14]=2[O:23][CH3:24])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:25]I>>[CH3:1][C:2]1[N:11]=[C:10]([N:12]([C:13]2[C:18]([O:19][CH3:20])=[CH:17][C:16]([O:21][CH3:22])=[CH:15][C:14]=2[O:23][CH3:24])[CH3:25])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 579388022-Methyl-N-(2,4,6-trimethoxyphenyl)quinazolin-4-amine

Product 1

HCID 111985624-Quinazolinamine, N,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-

Procedure

The title compound was prepared from (2-methyl-quinazolin-4-yl)-(2,4,6-trimethoxy-phenyl)-amine (56 mg, 0.17 mmol) and methyl iodide (0.1 ml, 1.6 mmol) by a procedure similar to Example 36. 1H NMR (CDCl3): 7.70 (d, J=8.4 Hz, 1H), 7.49 (t, J=7.8 Hz, 1H), 7.09 (d, J=8.7 Hz, 1H), 6.93 (t, J=8.1 Hz, 1H), 6.18 (s, 2H), 3.86 (s, 3H), 3.63 (s, 6H), 3.44 (s, 3H), 2.70 (s, 3H).

Sources & evidence

ORD record
ord-c14f4ac463724b99a0aa4fd2cded1aa4
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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