4-Ethoxyaniline → 2-Chloro-N-(4-ethoxyphenyl)quinazolin-4-amine

HRID 1876121Notes

Reaction equation

HRID 1876121 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:13]([O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)[CH3:14]>>[Cl:1][C:2]1[N:11]=[C:10]([NH:20][C:19]2[CH:21]=[CH:22][C:16]([O:15][CH2:13][CH3:14])=[CH:17][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 90764-EthoxyanilineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 226927292-Chloro-N-(4-ethoxyphenyl)quinazolin-4-amine

Procedure

The title compound was prepared from 2,4-dichloroquinazoline and 4-ethoxyaniline by a procedure similar to Example 28 (32%). 1H NMR (CDCl3): 7.81 (m, 1H), 7.65 (m, 1H), 7.32 (m, 2H), 7.03 (m, 1H), 6.73 (m, 3H), 4.09 (q, J=7.2, 2H), 1.49 (t, J=7.2, 3H).

Sources & evidence

ORD record
ord-bd539cf5299b459ab3aea2824723214b
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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