4-Chloro-2-methylquinazoline → N-(5-Methoxypyrazin-2-yl)-N,2-dimethylquinazolin-4-amine

HRID 1876137Notes

Reaction equation

HRID 1876137 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]([CH3:20])[N:11]=2)=[N:7][CH:8]=1.N[C:22]1C=NC(OC)=CN=1.ClC1C2C(=CC=CC=2)N=C(C)N=1>>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([N:9]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]([CH3:20])[N:11]=2)[CH3:22])=[N:7][CH:8]=1

Participants

4

Reactant 3

HCID 27854214-Chloro-2-methylquinazolineHCID 145364295-Methoxypyrazin-2-amineHCID 42625839N-(5-Methoxypyrazin-2-yl)-2-methylquinazolin-4-amine

Product 1

HCID 42625913N-(5-Methoxypyrazin-2-yl)-N,2-dimethylquinazolin-4-amine

Procedure

(5-Methoxy-pyrazin-2-yl)-(2-methyl-quinazolin-4-yl)-amine: The title compound was prepared from 2-amino-5-methoxy-pyrazine (105 mg, 0.84 mmol) and 4-chloro-2-methyl-quinazoline (150 mg, 0.84 mmol) by a procedure similar to Example 125c, yielding 106 mg of the title product.

Sources & evidence

ORD record
ord-c8d6cf6c5533459182f659a09cb58243
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

Loading…