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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1876137Generated: October 31, 2026

4-Chloro-2-methylquinazoline → N-(5-Methoxypyrazin-2-yl)-N,2-dimethylquinazolin-4-amine

https://huagongshe.com/reaction/1876137

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-2-methylquinazolineHCID 2785421—
Reactant5-Methoxypyrazin-2-amineHCID 14536429—
ReactantN-(5-Methoxypyrazin-2-yl)-2-methylquinazolin-4-amineHCID 42625839—
ProductN-(5-Methoxypyrazin-2-yl)-N,2-dimethylquinazolin-4-amineHCID 42625913—

Reaction Steps

(5-Methoxy-pyrazin-2-yl)-(2-methyl-quinazolin-4-yl)-amine: The title compound was prepared from 2-amino-5-methoxy-pyrazine (105 mg, 0.84 mmol) and 4-chloro-2-methyl-quinazoline (150 mg, 0.84 mmol) by a procedure similar to Example 125c, yielding 106 mg of the title product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08309562B2
Source datasetuspto-grants-2012_11
ORD IDord-c8d6cf6c5533459182f659a09cb58243
Source noteuspto-grants-2012_11