Dimethylamine → HCID 57938791, compound

HRID 1876139Notes

Reaction equation

HRID 1876139 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:22][NH:23][CH3:24].CO>>[CH3:22][N:23]([CH3:24])[C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 887MethanolHCID 11558497(2-chloro-quinazolin-4-yl)-(6-methoxy-pyridin-3-yl)-methylamine

Product 1

HCID 57938791HCID 57938791, compound

Procedure

The title compound was prepared from (2-chloro-quinazolin-4-yl)-(6-methoxy-pyridin-3-yl)-methyl-amine (69 mg, 0.23 mmol) and 2.0 M dimethylamine in methanol (4 ml, 8 mmol) by a procedure similar to Example 122 (51%). 1H NMR (CDCl3): 8.02 (d, J=2.7 Hz, 1H), 7.47 (d, J=8.1 Hz, 1H), 7.38-7.34 (m, 2H), 6.93 (d, J=8.4 Hz, 1H), 6.75-6.66 (m, 2H), 3.94 (s, 3H), 3.51 (s, 3H), 3.30 (s, 6H).

Sources & evidence

ORD record
ord-44c63c768a7d43c4bbb4fa2676ce4c50
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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