4-Aminopyridine → 2-Methyl-N-(pyridin-4-yl)quinazolin-4-amine

HRID 1876141Notes

Reaction equation

HRID 1876141 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1>>[CH3:12][C:4]1[N:3]=[C:2]([NH:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1

Participants

3

Reactant 2

HCID 17274-AminopyridineHCID 27854214-Chloro-2-methylquinazoline

Product 1

HCID 579388102-Methyl-N-(pyridin-4-yl)quinazolin-4-amine

Procedure

The title compound was prepared from 4-chloro-2-methyl-quinazoline and 4-amino-pyridine by a procedure similar to Examples 100. 1H NMR (CDCl3): 8.58 (m, 1H), 7.79-7.93 (m, 5H), 7.70 (s, broad, 1H), 7.55 (ddd, J=1.2, 6.9, 8.1, 1H), 2.79 (s, 3H).

Sources & evidence

ORD record
ord-31d0a38f54174d9a90104a6131a5318e
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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