N-Methyl-4-[(propan-2-yl)oxy]aniline → (4-Isopropoxy-phenyl)-methyl-(2-methyl-6-nitro-quinazolin-4-yl)-amine

HRID 1876204Notes

Reaction equation

HRID 1876204 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[C:4]([CH3:15])[N:3]=1.[CH:16]([O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][CH3:27])=[CH:22][CH:21]=1)([CH3:18])[CH3:17]>>[CH:16]([O:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]([CH3:27])[C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=3)[N:5]=[C:4]([CH3:15])[N:3]=2)=[CH:22][CH:21]=1)([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 18002910N-Methyl-4-[(propan-2-yl)oxy]anilineHCID 249038664-Chloro-2-methyl-6-nitroquinazoline

Product 1

HCID 59242034(4-Isopropoxy-phenyl)-methyl-(2-methyl-6-nitro-quinazolin-4-yl)-amine

Procedure

The title compound was synthesized from 4-chloro-2-methyl-6-nitro-quinazoline and (4-isopropoxy-phenyl)-methyl-amine by a procedure similar to Example 1b. 1H NMR (DMSO-d6) δ 8.5-7.1 (7H), 4.73 (m, 1H), 3.7 (s, 3H), 2.7 (s, 3H), 1.32 (d, 6H); LC-MS (ESI+; 353 ([M+H]+)).

Sources & evidence

ORD record
ord-cf64cfeae171492b88a936ded2555c07
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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