2-Hydroxy-2-methylpropanehydrazide → 2-hydroxy-N-[(Z)-(6-methoxy-2-oxo-1-pentylindol-3-ylidene)amino]-2-methylpropanamide
Reaction equation
[CH2:1]([N:6]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[C:9](=O)[C:7]1=[O:8])[CH2:2][CH2:3][CH2:4][CH3:5].[OH:19][C:20]([CH3:26])([CH3:25])[C:21]([NH:23][NH2:24])=[O:22]>>[OH:19][C:20]([CH3:26])([CH3:25])[C:21]([NH:23]/[N:24]=[C:9]1\[C:7](=[O:8])[N:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[C:16]2[C:11]\1=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)=[O:22]Participants
3
Procedure
The title compound was prepared as a yellow solid, using 1-pentyl-6-methoxy-isatin obtained in Example 39(A) and 2-hydroxy-2-methylpropanohydrazide according to the synthetic method E. NMR (CDCl3): δ 0.91 (t, 3H), 1.36 to 1.39 (m, 4H), 1.59 (s, 6H), 1.87 (m, 3H), 2.63 (s, 1H), 3.68 (t, 2H), 3.87 (s, 3H), 6.41 (d, 1H), 6.61 (dd, 1H), 7.73 (d, 1H), 13.71 (br s, 1H).
Sources & evidence
- ORD record
- ord-1f85ab287eda43cdb0c2f5adfcd94a23
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08309595B2
Reaction notes
Loading…