2-Cyclohexylacetohydrazide → HCID 178446194, compound

HRID 1876272Notes

Reaction equation

[CH2:1]([N:6]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[C:9](=O)[C:7]1=[O:8])[CH2:2][CH2:3][CH2:4][CH3:5].[CH:19]1([CH2:25][C:26]([NH:28][NH2:29])=[O:27])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:19]1([CH2:25][C:26]([NH:28]/[N:29]=[C:9]2\[C:7](=[O:8])[N:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[C:16]3[C:11]\2=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=3)=[O:27])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

Reactant 2

HCID 38186732-Cyclohexylacetohydrazide

HCID 251944561-Pentyl-6-methoxy-isatin

Product 1

HCID 178446194HCID 178446194, compound

Procedure

The title compound was prepared as a yellow solid, using 1-pentyl-6-methoxy-isatin obtained in Example 39(A) and 2-cyclohexylacetohydrazide according to the synthetic method E. NMR (CDCl3): δ 0.91 (t, 3H), 1.01-1.07 (m, 2H), 1.18 to 1.39 (m, 7H), 1.60-1.72 (m, 5H), 1.81 (d, 2 H), 1.92-1.94 (m, 1H), 2.27 (d, 1H), 2.69 (d, 1H), 3.70 (t, 2H), 3.87 (s, 3H), 6.42 (s, 1H), 6.62 (d, 1H), 7.52 and 7.74 (d for isomers, 1H), 12.39 and 13.99 (br s for isomers, 1H).

Sources & evidence

ORD record: ord-2c34ba923b904edeaea85f2f14a0aa7e
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309595B2

Reaction notes

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