2-(4-Morpholinyl)acetohydrazide → HCID 178446204, compound

HRID 1876274Notes

Reaction equation

HRID 1876274 reaction equation
[CH2:1]([N:6]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[C:9](=O)[C:7]1=[O:8])[CH2:2][CH2:3][CH2:4][CH3:5].[N:19]1([CH2:25][C:26]([NH:28][NH2:29])=[O:27])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[CH3:18][O:17][C:14]1[CH:15]=[C:16]2[C:11](/[C:9](=[N:29]/[NH:28][C:26](=[O:27])[CH2:25][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)/[C:7](=[O:8])[N:6]2[CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 3516352-(4-Morpholinyl)acetohydrazideHCID 251944561-Pentyl-6-methoxy-isatin

Product 1

HCID 178446204HCID 178446204, compound

Procedure

The title compound was prepared as a yellow solid, using 1-pentyl-6-methoxy-isatin obtained in Example 39(A) and 2-morpholin-4-ylacetohydrazide according to the synthetic method E. NMR (CDCl3): δ 0.92 (t, 3H), 1.26 (s, 1H), 1.36 to 1.39 (m, 5H), 1.64-1.72 (m, 4H), 2.61 (d, 4H), 3.29 (s, 2H), 3.84-3.87 (m, 8H), 6.41 (d, 1H), 6.60 (dd, 1H), 7.75 (d, 2H), 13.86 (br s, 1H).

Sources & evidence

ORD record
ord-b92a2b80eea44b3f847a2230e1d8896f
Source dataset
uspto-grants-2012_11
Patent number
US08309595B2

Reaction notes

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