2-Bromoethyl methyl ether → HCID 25194459, compound

HRID 1876276Notes

Reaction equation

HRID 1876276 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[O:13])[C:8](=[O:12])[NH:9]2)=[CH:5][CH:4]=1.[CH3:14][O:15][CH2:16][CH2:17]Br>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[O:13])[C:8](=[O:12])[N:9]2[CH2:17][CH2:16][O:15][CH3:14])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 103749726-Methoxyisatin

Product 1

HCID 25194459HCID 25194459, compound

Procedure

The title compound was prepared as a red solid, using 6-methoxy-isatin prepared as described in Pavlidis et al. and 2-bromoethyl methyl ether following Method B. Pavlidis, V. H., et al., The Synthesis of a Novel Series of Substituted 2-Phenyl-4H-3,1-benzoxazin-4-ones, Synthetic Communications, 1994, 24:4, 533-548. NMR (CDCl3): δ 3.35 (s, 3H), 3.65 (t, 2H), 3.87 (s, 3H), 3.94 (t, 2H), 6.64 (d, 1H), 7.58 (t, 1H), 7.79 (d, 1H), 13.93 (br s, 1H).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-ccf13d719ff6425a962d3ab323e796ea
Source dataset
uspto-grants-2012_11
Patent number
US08309595B2

Reaction notes

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