2-Morpholinoethylamine → HCID 59543009, compound

HRID 1876317Notes

Reaction equation

HRID 1876317 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([OH:25])=O)[N:21]=1)=[CH:5]2.[NH2:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([NH:26][CH2:27][CH2:28][N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[O:25])[N:21]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 25196145[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid

Product 1

HCID 59543009HCID 59543009, compoundYield 34%

Procedure

The compound (50 mg, 0.13 mmol) prepared in Example 27 and 4-(2-aminoethyl)morpholine instead of morpholine were reacted according to the same procedure as Example 73 to give the title compound (22 mg, Yield 34%).

Sources & evidence

ORD record
ord-46c09d0f084144648f7035b372c5d818
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

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