N-(3-Aminopropyl)morpholine → HCID 59543017, compound

HRID 1876318Notes

Reaction equation

HRID 1876318 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([OH:25])=O)[N:21]=1)=[CH:5]2.[NH2:26][CH2:27][CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([NH:26][CH2:27][CH2:28][CH2:29][N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[O:25])[N:21]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 25196145[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid

Product 1

HCID 59543017HCID 59543017, compoundYield 35%

Procedure

The compound (50 mg, 0.13 mmol) prepared in Example 27 and 4-(3-aminopropyl)morpholine instead of morpholine were reacted according to the same procedure as Example 73 to give the title compound (23 mg, Yield 35%).

Sources & evidence

ORD record
ord-19e0b25410e24cd492d551460dd8fb97
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

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