3-(Dimethylamino)pyrrolidine → HCID 59543030, compound

HRID 1876322Notes

Reaction equation

HRID 1876322 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([OH:25])=O)[N:21]=1)=[CH:5]2.[CH3:26][N:27]([CH3:33])[CH:28]1[CH2:32][CH2:31][NH:30][CH2:29]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:13][CH2:14][CH2:15][CH2:16]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([N:30]3[CH2:31][CH2:32][CH:28]([N:27]([CH3:33])[CH3:26])[CH2:29]3)=[O:25])[N:21]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 27585193-(Dimethylamino)pyrrolidineHCID 25196145[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid

Product 1

HCID 59543030HCID 59543030, compoundYield 48%

Procedure

The compound (40 mg, 0.11 mmol) prepared in Example 27 and 3-dimethylaminopyrrolidine instead of morpholine were reacted according to the same procedure as Example 73 to give the title compound (24 mg, Yield 48%).

Sources & evidence

ORD record
ord-4cb80607f8594f2e9b08a763d94ee2c7
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

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