HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxypyrrolidine → 2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-1-(3-hydroxy-pyrrolidin-1-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | [(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid | HCID 25196145 | — |
| Product | 2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-1-(3-hydroxy-pyrrolidin-1-yl)-ethanone | HCID 59542985 | 40% |
Reaction Steps
The compound (40 mg, 0.11 mmol) prepared in Example 27 and 3-pyrrolidinol instead of morpholine were reacted according to the same procedure as Example 73 to give the title compound (19 mg, Yield 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309586B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-19bddf3fcf534be588ea429e9c465d67 |
| Source note | uspto-grants-2012_11 |