Piperidine → HCID 59543084, compound

HRID 1876324Notes

Reaction equation

HRID 1876324 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23](O)=[O:24])[N:21]=1)=[CH:5]2.[NH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([N:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)=[O:24])[N:21]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 8082PiperidineHCID 25196145[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid

Product 1

HCID 59543084HCID 59543084, compoundYield 57%

Procedure

The compound (40 mg, 0.11 mmol) prepared in Example 27 and piperidine instead of morpholine were reacted according to the same procedure as Example 73 to give the title compound (27 mg, Yield 57%).

Sources & evidence

ORD record
ord-00c6d378d43143a88169d953d90172d3
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

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