2-Morpholinoethylamine → HCID 59543008, compound

HRID 1876328Notes

Reaction equation

[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([F:25])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][C:22](O)=[O:23])[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([F:25])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][C:22]([NH:26][CH2:27][CH2:28][N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)=[O:23])[N:20]=2)=[CH:12]3)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 59543018HCID 59543018, compound

Product 1

HCID 59543008HCID 59543008, compoundYield 60%

Procedure

The compound (100 mg, 0.28 mmol) prepared in Example 37 and 4-(2-aminoethyl)morpholine instead of 1-methylpiperazine were reacted according to the same procedure as Example 84 to give the title compound (80 mg, Yield 60%).

Sources & evidence

ORD record: ord-c83f07f5b45145bb901192a94b19e3b6
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309586B2

Reaction notes

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