1,4-Dioxane hydrochloride → HCID 59543058, compound

HRID 1876339Notes

Reaction equation

HRID 1876339 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C@@H:15]2[CH2:19][S:18][C:17]([C:20]3[NH:21][C:22]4[C:27]([CH:28]=3)=[CH:26][C:25]([Cl:29])=[CH:24][C:23]=4[NH:30][CH:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)=[N:16]2)[CH2:9]1)(C)(C)C.O1CCOCC1.Cl>ClCCl>[NH2:7][C@H:8]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C@@H:15]2[CH2:19][S:18][C:17]([C:20]3[NH:21][C:22]4[C:27]([CH:28]=3)=[CH:26][C:25]([Cl:29])=[CH:24][C:23]=4[NH:30][CH:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)=[N:16]2)[CH2:9]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59542949HCID 59542949, compound

Product 1

HCID 59543058HCID 59543058, compoundYield 76.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (150 mg, 0.27 mmol) prepared in Example 114 was dissolved in dichloromethane (30 ml). 4N hydrochloric acid dioxane solution (0.34 ml, 1.35 mmol) was added thereto, and the mixture was stirred for 4 h at room temperature. After completion of the reaction, the reaction solution was distilled under reduced pressure to give a solid. The solid was washed with ethylether, and dried to give the title compound (92 mg, Yield 75%).

Workup

  1. customAfter completion of the reaction
  2. distillationthe reaction solution was distilled under reduced pressure
  3. customto give a solid
  4. washThe solid was washed with ethylether
  5. customdried

Sources & evidence

ORD record
ord-6e540a2736e64831b0c9a8a75048c561
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

Loading…