2-Morpholinoethylamine → HCID 59543001, compound

HRID 1876344Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][CH2:23][C:24]([OH:26])=O)[N:21]=1)=[CH:5]2.[NH2:27][CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][CH2:23][C:24]([NH:27][CH2:28][CH2:29][N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[O:26])[N:21]=1)=[CH:5]2

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 25195718HCID 25195718, compound

Product 1

HCID 59543001HCID 59543001, compoundYield 26%

Procedure

The compound (150 mg, 0.38 mmol) prepared in Example 149 and 4-(2-aminoethyl)morpholine instead of morpholine were reacted according to the same procedure as Example 70 to give the title compound (50 mg, Yield 26%).

Sources & evidence

ORD record: ord-c97089a7e06e4417abb2edc0598341ce
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309586B2

Reaction notes

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