1-Methylpiperazine → HCID 59542954, compound

HRID 1876345Notes

Reaction equation

HRID 1876345 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][CH2:23][C:24](O)=[O:25])[N:21]=1)=[CH:5]2.[CH3:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][CH2:23][C:24]([N:31]3[CH2:32][CH2:33][N:28]([CH3:27])[CH2:29][CH2:30]3)=[O:25])[N:21]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 25195718HCID 25195718, compound

Product 1

HCID 59542954HCID 59542954, compoundYield 28%

Procedure

The compound (150 mg, 0.38 mmol) prepared in Example 149 and 1-methylpiperazine instead of morpholine were reacted according to the same procedure as Example 73 to give the title compound (50 mg, Yield 28%).

Sources & evidence

ORD record
ord-5b0f79192d76456bb1b75ae0614944e6
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

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