Triphenylphosphine → HCID 86643715, compound

HRID 1876387Notes

Reaction equation

HRID 1876387 reaction equation
[Cl:1][CH2:2][C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[CH:6]=[C:5]([F:14])[CH:4]=1.[C:15]1([P:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[Cl-:1].[F:14][C:5]1[CH:4]=[C:3]([CH2:2][P+:21]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 58566560HCID 58566560, compound

Product 1

HCID 86643715HCID 86643715, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-(chloromethyl)-5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran (647) (1 g, 4.66 mmol), triphenyl phosphine (1.22 g, 4.66 mmol) and toluene (46 mL) were heated at reflux for 48 hours. The reaction was filtered and the solid was washed with diethyl ether to provide ((5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methyl)triphenyl phosphonium chloride (648).

Workup

  1. temperatureat reflux for 48 hours
  2. filtrationThe reaction was filtered
  3. washthe solid was washed with diethyl ether

Sources & evidence

ORD record
ord-6d5521794b114b9583117644b97740b6
Source dataset
uspto-grants-2012_11
Patent number
US08309600B2

Reaction notes

Loading…