2-Methylallyl 2,3-difluoro-6-(2-methylallyloxy)benzoate → 2-Methylallyl 2,3-difluoro-6-hydroxy-5-(2-methylallyl)benzoate

HRID 1876428Notes

Reaction equation

HRID 1876428 reaction equation
[F:1][C:2]1[C:14]([F:15])=[CH:13][CH:12]=[C:11]([O:16]CC(C)=C)[C:3]=1[C:4]([O:6][CH2:7][C:8]([CH3:10])=[CH2:9])=[O:5]>CN1C(=O)CCC1>[F:1][C:2]1[C:14]([F:15])=[CH:13][C:12]([CH2:4][C:3]([CH3:11])=[CH2:2])=[C:11]([OH:16])[C:3]=1[C:4]([O:6][CH2:7][C:8]([CH3:10])=[CH2:9])=[O:5]

Participants

3

Reactant 1

HCID 585667032-Methylallyl 2,3-difluoro-6-(2-methylallyloxy)benzoate

Product 1

HCID 585663922-Methylallyl 2,3-difluoro-6-hydroxy-5-(2-methylallyl)benzoateYield 200%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A solution of 2-methylallyl 2,3-difluoro-6-(2-methylallyloxy)benzoate (733) (1.53 g, 5.42 mmol) in NMP (3.5 mL) was heated in the microwave at 200° C. for 6 h. The solvent was removed in vacuo to provide 2-methylallyl 2,3-difluoro-6-hydroxy-5-(2-methylallyl)benzoate (734) (1.53 g) which was directly used in the next step reaction without further purification.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-a6ce367e5f7e4aa0bdfebc444e8f2b85
Source dataset
uspto-grants-2012_11
Patent number
US08309600B2

Reaction notes

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