反应详情

Sodium carbonate (3.25 g, 30.6 mmol) and tetrakis triphenylphosphine palladium (0.59 g, 0.51 mmol) were added to a 1,4-dioxane (60.0 ml)-water (30.0 ml) mixture solution of 2-chloro-9-(cyclopropylmethyl)-6-morpholin-4-yl-9H-purine (3.0 g, 10.2 mmol) and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (2.5 g, 11.2 mmol) at room temperature and the resulting mixture was heated to reflux for 3 hours in an argon atmosphere. The reaction mixture was left standing to cool and then poured into water, and ethyl acetate was added to separate the layers. The solid precipitated in the aqueous layer was collected by filtration, washed with water, and dried at 50° C. under reduced pressure to give the title compound (3.63 g, 100%) as a white solid.

1. temperaturethe resulting mixture was heated
2. temperatureto reflux for 3 hours in an argon atmosphere
3. waitThe reaction mixture was left
4. temperatureto cool
5. additionwas added
6. customto separate the layers
7. customThe solid precipitated in the aqueous layer
8. filtrationwas collected by filtration
9. washwashed with water
10. customdried at 50° C. under reduced pressure