反应详情

5-{9-(Cyclopropylmethyl)-8-[4-(methylsulfonyl)piperazin-1-yl]-6-morpholin-4-yl-9H-purin-2-yl}pyrimidin-2-amine (149.4 mg, 0.29 mmol) was stirred in a dichloromethane-methanol (3:2) mixed solvent followed by the addition of methanesulfonic acid (18.7 μl, 0.29 mmol) at room temperature and the resulting mixture was stirred for 10 minutes. The reaction mixture was concentrated under reduced pressure and the resulting residue was dried at 60° C. under reduced pressure to give the title compound (176.7 mg, 100%) as a yellow solid.

1. additionmixed solvent
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe resulting residue was dried at 60° C. under reduced pressure